Deficiency of the Cysteine Protease Cathepsin S Impairs Microvessel Growth
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چکیده
منابع مشابه
Deficiency of the cysteine protease cathepsin S impairs microvessel growth.
During angiogenesis, microvascular endothelial cells (ECs) secrete proteinases that permit penetration of the vascular basement membrane as well as the interstitial extracellular matrix. This study tested the hypothesis that cathepsin S (Cat S) contributes to angiogenesis. Treatment of cultured ECs with inflammatory cytokines or angiogenic factors stimulated the expression of Cat S, whereas inh...
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Motivated by the recent implication of cysteine protease cathepsin L as a potential target for anti-cancer drug development, we used a conditional MycERTAM;Bcl-xL model of pancreatic neuroendocrine tumorigenesis (PNET) to assess the role of cathepsin L in Myc-induced tumor progression. By employing a cysteine cathepsin activity probe in vivo and in vitro, we first established that cathepsin act...
متن کاملThe lysosomal cysteine protease cathepsin L regulates keratinocyte proliferation by control of growth factor recycling.
Mice deficient for cathepsin L (CTSL) show epidermal hyperplasia due to a hyperproliferation of basal keratinocytes. Here we show that the critical function of CTSL in the skin is keratinocyte specific. This is revealed by transgenic re-expression of CTSL in the keratinocytes of ctsl-/- mice, resulting in a rescue of the ctsl-/- skin phenotype. Cultivation of primary mouse keratinocytes with fi...
متن کاملCathepsin K: a cysteine protease with unique kinin-degrading properties.
Taking into account a previous report of an unidentified enzyme from macrophages acting as a kininase, the ability of cysteine proteases to degrade kinins has been investigated. Wild-type fibroblast lysates from mice, by contrast with cathepsin K-deficient lysates, hydrolysed BK (bradykinin), and released two metabolites, BK-(1-4) and BK-(5-9). Cathepsin K, but not cathepsins B, H, L and S, cle...
متن کاملCorrection: Cathepsin E Deficiency Impairs Autophagic Proteolysis in Macrophages
Citation: The PLOS ONE Staff (2014) Correction: Cathepsin E Deficiency Impairs Autophagic Proteolysis in Macrophages. PLoS ONE 9(5): e99278. doi:10.1371/ journal.pone.0099278 Published May 27, 2014 Copyright: 2014 The PLOS ONE Staff. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduct...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2003
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.0000060485.20318.96